aldolases การใช้

This active site is located in the center of the homotetrameric ??-barrel structure of these aldolases.
The " P . falciparum " aldolase is a 41 kDa protein and has 61-68 % sequence similarity to known eukaryotic aldolases.
This is consistent with the notion that both enzymes belong to a superfamily of epimerases / aldolases that catalyze carbon-carbon bond cleavage reactions via a metal-stabilized enolate intermediate.
The name "'aldol condensation "'is also commonly used, especially in biochemistry, to refer to just the first ( addition ) stage of the process the aldol reaction itself as catalyzed by aldolases.
This reaction is typified by the formation of a Schiff base intermediate with a lysine residue ( lysine 229 ) in the active site of the enzyme; the formation of a Schiff base is the key differentiator between Class I ( produced by animals ) and Class II ( produced by fungi and bacteria ) aldolases.