aminoglutethimide การใช้

They include direct glucocorticoid receptor inhibitors such as metyrapone, ketoconazole, and aminoglutethimide.
Aminoglutethimide inhibits both aromatase and other enzymes critical for steroid hormone synthesis in the adrenal glands.
The loss of testosterone can cause liver damage with prolonged use, and aminoglutethimide can cause skin rashes.
The androgen synthesis inhibitors aminoglutethimide and ketoconazole were first marketed in 1960 and 1977, respectively, and the newer drug abiraterone acetate was introduced in 2011.
Another trial found an 18 percent response rate for Femara compared to an 11 percent response rate for the other drug, known as aminoglutethimide, or AG.