dichloroacetate การใช้

However, treatment with dichloroacetate does not improve neurological damage . Oral citrate is often used to treat acidosis.
Three proposed inhibitors are AZD7545 and dichloroacetate which both bind to PDK1, and Radicicol which binds to PDK3.
In rare chronic forms of lactic acidosis caused by mitochondrial disease, a specific diet or dichloroacetate may be used.
There is some evidence that dichloroacetate reduces the inhibitory phosphorylation of pyruvate dehydrogenase complex and thereby activates any residual functioning complex.
The antidote of chloroacetic acid poisoning is sodium dichloroacetate ( 50 mg / kg IV over 10 mins, repeated in 2h; double dosage if hemodialysis is performed ).