hypomorph การใช้

A hypomorph is a reduction in gene function through reduced ( protein, RNA ) expression or reduced functional performance, but not a complete loss.
Loss of Crim1 function as demonstrated by the Crim1 KST264 hypomorph mice resulted in onset of chronic kidney disease with accompanying pathology including papillary hypoplasia, functional urinary tract obstruction, ectopic collagen accumulation within the endothelium and tubulointerstitial fibrosis which was in part attributed by ( endothelial ) epithelial mesenchymal transition.
Hermann J . Muller ( 1890 & ndash; 1967 ), who was a 1946 Nobel Prize winner, coined the terms "'amorph, hypomorph, hypermorph, antimorph "'and "'neomorph "'to classify mutations based on their behaviour in various genetic situations, as well as gene interaction between themselves.