map3 การใช้

Importantly, this dimerisation event also forces the MAP3 kinase domains to adopt a partially active conformation.
Example for the inner workings of a MAP3 kinase : the activation cycle of mammalian Raf proteins ( greatly simplified overview ).
Once a MAP3 kinase is fully active, it may phosphorylate its substrate MAP2 kinases, which in turn will phosphorylate their MAP kinase substrates.
The MAP2 kinase of this pathway is called Pbs2 ( related to mammalian MKK3 / 4 / 6 / 7 ), the dedicated MAP3 kinases involved in activation are Ssk2 and SSk22.
The mating MAPK pathway consist of three tiers ( Ste11-Ste7-Fus3 ), but the MAP2 and MAP3 kinases are shared with another pathway, the Kss1 or filamentous growth pathway.