melanogenic การใช้

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This results in increased concentrations of the melanogenic enzymes within the melanocyte.
Inhibitors of melanogenesis whose mechanism of action includes reducing the genetic expression of melanogenic enzymes include caffeoylserotonin, AP736, pomegranate extract, and betulinic acid ( extracted from Vitis amurensis root ).
Until recently, it was believed that the probable ligand for OA1 might be within the melanosomal lumen, maybe one of the components of the melanogenic pathway since it is so closely related to melanosome biogenesis.
Thus, MSH-MC1R signaling leads to enhanced pigment synthesis by melanocytes and accumulation of melanin by epidermal keratinocytes . [ " etcetera " ] The MC1R is found on the surface of melanocytes where it binds to ?-melanocyte stimulating hormone ( MSH ) and transmits differentiation signals into the cell through activation of adenylyl cyclase and generation of cAMP [ " references omitted " ] . cAMP signaling leads to activation of the protein kinase A ( PKA ) cascade which, in turn, leads to increased levels and / or activity of many melanogenic enzymes to enhance production and export of melanin by melanocytes [ " references and figure omitted " ] . " } } beta-melanocyte stimulating hormone ( ?-MSH ) and adrenocorticotropic hormone are endogenous agonists of MC1R . Agouti signaling protein ( ASIP ) appears to be the only endogenous antagonist of MC1R . } } Synthetic MC1R agonists have been designed; examples include the peptides afamelanotide and melanotan II.

melanogenic การใช้

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