neurolysin การใช้

In vitro, neurolysin exemplifies the ability of some neuropeptidases to target diverse cleavage site sequences.
Neurolysin, with 704 amino acid residues, is a zinc metalloendopeptidase with a conserved HEXXH domains.
Neurolysin hydrolyzes only peptides containing 5-17 amino acids by cleaving at a limited set of sites.
The specificity of neurolysin for small bioactive peptides is due to the presence of large structural elements erected over its active site region that allow substrates access only through a deep narrow channel.
Metabolism of neurotensin is the most important role of neurolysin in vivo and has been identified as a non-AT1-non-AT2 angiotensin-binding site . and control of neurotensin levels by neurolysin may serve as a potential target for antipsychotic therapies.