phosphotyrosine การใช้

PTP1B can dephosphorylate the phosphotyrosine residues of the activated insulin receptor kinase.
Mass spectrometry is subsequently used to identify phosphoserine, phosphothreonine, and phosphotyrosine-containing peptides.
These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine / threonine and phosphotyrosine residues.
Mutations in the SH2 and SH3 domains that disrupt binding of phosphotyrosine lead to activation of kinase activity.
The gene for CCM2 encodes a novel protein named malcavernin that contains a phosphotyrosine ( PTB ) binding domain.