ppiase การใช้

The PPIase domain is homologous to PPIA and can be bound and inhibited by CsA.
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase ( PPIase ) family.
In addition to PPIase and protein chaperone activities, cyclophilins function in mitochondrial metabolism, apoptosis, immunological response, inflammation, and cell growth and proliferation.
This protein is the major PPIase for type I collagen, since the collagen contains an abundance of prolines that require cis-trans isomerization for proper folding.
In particular, PPIE contains two RNA-binding domains at the N-terminal and a 165-bases long PPIase domain at the C-terminal.