prereplicative การใช้

A licensing factor which is required for replication initiation binds to origins in the prereplicative state.
Entry into S-phase during endoreplication ( and mitosis ) is regulated through the formation of a prereplicative complex ( pre-RC ) at replication origins, followed by recruitment and activation of the DNA replication machinery.
Early experimental evidence on the regulation of DNA replication suggests that replication origins exist in one of two states during the cell cycle : a prereplicative state in G1 and a postreplicative state from the moment of initiation until passage through mitosis.