radioautography การใช้

ประโยค

"In 1946, after returning to Montreal from service with the Free French Forces, it was clear to me that the crude technique previously used for radioautography had to be improved ".
From 1980-84 he worked on a project " Drug Action, brain development and behavioral changes in the mammalian system " financed by CSIR ( India ) . This work mainly led to the finding that action of some CNS acting drugs are potentiated in undernourished animals . They also observed that the drug reserpine is a strong inhibitor of lipid peroxidation and protein phosphorylation in brain . This project was mainly concerned with interaction between drug action, monoamines and membrane phenomenon which could later be extra polated to behaviour . Since various gangliosides are involved in binding of cerebral amines the contents of different species of gangliosides and neuraminidase activity was established . He established that the drug reerpine effects the cationiv content of rat brain and proposed that changes in cationic content may be playing a part in release of monoamines at the synapse . It was further shown that transport property of isolated cerebral tissue is altered in chronic reserpinized animals which further pointed out the membrane action of reserpine . In 1980 he established that there is a relationship between high density lipoproteins and premature atherosclerosis in patients with renal failure . The work on lipoproteins was also carried out with patients suffering from anxiety neurosis . He was one of the coinvestigators in an international study on protein energy requirements in indivisuals of this country and this work was supported by the United Nations University . In addition he was involved in a number of collaborative studies with various groups in the institute . The studies include Biochemical and Immunological studies in chylurya, placental oxidative enzymes in pregnancy anemia, Lecithin-Sphingomyelin ratio in fetal lung maturity etc . Till August 2000 he was involved in study of protein phosphorylation in brain . He had shown that protein phosphorylation is adversely on rehabilation . Attempts were in progress to characterize specific proteins by SDSPAGE and radioautography . He had shown the effect of pentobarbitone on cerebral protein phosphorylation which is not due to to its action on electron transport chain . Work was also in progress in his laboratory till August 2000 to study effect of a number of CNS drugs on protein phosphorylation in brain and to examine if specific proteins are effected . This would have helped to establish exact role of cerebral phosphoproteins in neurotransmission . Mechanism of action of some antiepileptic drugs on brain metabolism was also in progress . In 1999 he conclusively established that in conditions like Alzeihmer's disease there is phosphorylation related folding problem of proteins . This is responsible for cognitive and other defects . Similar situation exists under severe undernutrition during brain growth spurt period and similar mechanism involving protein phosphorylation may be involved here also.

radioautography การใช้

ประโยค

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