thrombopenias การใช้

In the circulatory system, several forms of anemia and other blood dyscrasias ( leukopenia, thrombopenia ), serious cardiac arrhythmias ( including ventricular fibrillation ), and even frank cardiac failure have been reported.
Inhibition of JAK2 may also contribute to the efficacy against RA . Nonetheless it is thought that JAK2 inhibition might lead to anemia and thrombopenia by interference with erythropoietin and thrombopoietin and granulocyte-macrophage colony-stimulating factor.
Many patients with aplastic anemia also have clones of cells characteristic of the rare disease paroxysmal nocturnal hemoglobinuria ( PNH, anemia with thrombopenia and / or thrombosis ), sometimes referred to as AA / PNH . Occasionally PNH dominates over time, with the major manifestation intravascular hemolysis.
Rare side effects include flushing of the face, hyperhidrosis ( excessive sweating ), cutaneous eruption, arterial hypotension, tachycardia, loss of appetite, jaundice, eosinophilia, thrombopenia, mixed hepatitis, headache, allergic reaction, chronic active hepatitis, and paradoxical aggravation of cerebral vasospasm.