unphysiological การใช้

At the same time it prevents an unphysiological accumulation of metabolic products and an overshoot of paracrine factors.
However, these conclusions were drawn from " in vitro " experiments under unphysiological conditions, and the physiological role of the G ?? complex in vision is still unclear.
Opponents of the ceRNA hypothesis point out that irrefutable proof of ceRNA-mediated gene regulation still remains to be shown, since most studies either overexpress RNA transcripts at unphysiological levels or lack seed mutation controls when up-or down-regulating potential ceRNA transcripts.
The reasons for this are 1 ) the absence of validated " in vivo " biomarkers, especially for inflammation or carcinogenesis; 2 ) long-term studies failing to demonstrate effects with a mechanism of action, specificity or efficacy; and 3 ) invalid applications of high, unphysiological test concentrations in the " in vitro " studies, which are subsequently irrelevant for the design of " in vivo " experiments.