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alpha cell การใช้

ประโยคมือถือ
  • Alpha cells produce glucagon and beta cells produce insulin.
  • They also inhibit glucagon release from the alpha cells of the islets of Langerhans.
  • Endocrine lineages develop into Delta cells, PP-cells, Epsilon cells, Beta cells and Alpha cells.
  • It is generated in the alpha cells of the pancreas and in the intestinal L cells in the distal ileum and colon.
  • PEPCK-C activity is increased upon the secretion of both cortisol from the adrenal cortex and glucagon from the alpha cells of the pancreas.
  • In the beta cells of the pancreatic islets, it serves as a glucose sensor to control insulin release, and similarly controls glucagon release in the alpha cells.
  • As the blood and glucose flow into the pancreas, insulin and amylin are co-secreted by the pancreatic alpha cells will release glucagon directly into the bloodstream.
  • The endocrine cells constitute the beta cells which make insulin, alpha cells which secrete glucagon, delta cells which secrete somatostatin and the PP-cells which secrete pancreatic polypeptide.
  • Trichrome methods are now used for differentiating muscle from collagen, pituitary alpha cells from beta cells, fibrin from collagen, and mitochondria in fresh frozen muscle sections, among other applications.
  • When the beta cells in the pancreatic islets detect lower than normal blood glucose levels, insulin secretion into the blood ceases and the alpha cells are stimulated to secrete glucagon into the blood.
  • There is an inability to excrete H + while cannot be reclaimed by the cell, leading to acidemia ( as builds up in the body ) and hypokalemia ( as cannot be reabsorbed by the alpha cell ).
  • The hormone glucagon was discovered by C . P . Kimball and John R . Murlin in 1923 as a cobalt-damage alpha cells stopped producing glucagon in guinea pigs, and finally isolated the purified hormone in 1953, including those from birds.
  • If the blood glucose level drops lower than this, especially to dangerously low levels, release of hyperglycemic hormones ( most prominently glucagon from islet of Langerhans alpha cells ) forces release of glucose into the blood from the liver glycogen stores, supplemented by gluconeogenesis if the glycogen stores become depleted.