angiotensin ii type 2 receptor การใช้

• EMA401 target proteins, angiotensin II type 2 receptors, are extremely important for nociception within the peripheral nervous system and less so for nociception within other functional systems.
• EMA401 is the first drug on the market that targets angiotensin II type 2 receptors ( ATR ) with high affinity but has a low affinity for angiotensin II type 1 receptors.
• These investigations led to the discovery of two subtypes of membrane bound G protein-coupled angiotensin receptors within the renin-angiotensin system with vastly different functions : angiotensin II type 1 receptors ( ATR ) and angiotensin II type 2 receptors ( ATR ).
• By 2020, the neuropathic pain treatment market is projected to reach $ 3.6 billion USD . The report on those six drugs was the first to clearly elucidate the role of angiotensin II type 2 receptors in neuropathic pain and implicated ATR antagonists as potential drugs for the treatment of neuropathic pain.