binary cell การใช้

• Numb protein signaling plays a key role in binary cell fate decisions following asymmetric cell divisions.
• Specifically, HES1 influences the timing of differentiation by repressing bHLH activators, and determines binary cell fate.
• The numb gene protein product controls binary cell fate decisions in the peripheral and central nervous systems of both invertebrates and mammals during neurogenesis.
• This same pathway operates to mediate binary cell fate decisions in " trans-Golgi network, and presented on the cell surface as a heterodimer.
• Transcriptional analysis and gain of function experiments revealed that Notch signaling targets Hes1 in the intestine and regulates a binary cell fate decision between adsorptive and secretory cell fates.
• Thus, lateral inhibition mechanisms are key to Notch signaling . " lin-12 " and " Notch " mediate binary cell fate decisions, and lateral inhibition involves feedback mechanisms to amplify initial differences.