connexins การใช้

• Gap junctions are made of connexins in vertebrates and innexins in invertebrates.
• Connexons are an example of a homomultimeric protein composed of six identical connexins.
• Probenecid did not affect channels formed by connexins.
• See GJB2 for additional background information on connexins.
• Cancer cells will often communicate via gap junctions, which are proteins known as connexins.
• Alternatively, drugs could target complementary connexins, such as Cx40, which function similarly to GJA1.
• Connexins associate in groups of 6 and are organized radially around a central pore to form connexons.
• In turn, hemichannels of uniform connexin composition are called homomeric, while those with differing connexins are heteromeric.
• It is likely this early work was already reflecting the presence of more than just connexins in gap junctions.
• Connexins span the plasma membrane 4 times, with amino-and carboxy-terminal regions facing the cytoplasm.
• This gene is a member of the large family of connexins that are required for the formation of gap junctions.
• In the male genital ridge, transient gap and desmosomelike junctions as well as adherins junctions composed of cadherins and connexins.
• These connexins have been shown to suppress cancer cells, but this suppression is not the only thing that connexins facilitates.
• These connexins have been shown to suppress cancer cells, but this suppression is not the only thing that connexins facilitates.
• The gap junction channels have unique properties depending on the type of connexins constituting the channel . [ supplied by OMIM]
• Connexons made of the same type of connexins are considered homomeric, while connexons made of differing types of connexins are heteromeric.
• Connexons made of the same type of connexins are considered homomeric, while connexons made of differing types of connexins are heteromeric.
• Probenecid, a well-established drug for the treatment of gout, allows for discrimination between channels formed by connexins and pannexins.
• Connexins are membrane-spanning proteins that assemble to form gap junction channels that facilitate the transfer of ions and small molecules between cells.
• Gap junction proteins are members of a large family of homologous connexins and comprise 4 transmembrane, 2 extracellular, and 3 cytoplasmic domains.