corticotropin releasing hormone การใช้

• Administration of corticotropin releasing hormone ( CRH ) can differentiate this condition from ectopic ACTH secretion.
• Hormones which have been studied include estrogen, progesterone, thyroid hormone, testosterone, corticotropin releasing hormone, and cortisol.
• Corticotropin releasing hormone ( CRH ) from the hypothalamus stimulates ACTH release in a cascading effect that ends with the production of glucocorticoids from the adrenal cortex.
• The N-terminal signal peptides of corticotropin releasing hormone receptor 1 and CRHR2 beta are cleaved off in the endoplasmic reticulum to yield the mature receptors.
• Stimulation of 5-HT 2C receptors leads to increase of corticotropin releasing hormone ( CRH ) and vasopressin mRNA in the paraventricular nucleus and proopiomelanocortin in the anterior pituitary lobe.
• Activation of Y 1 is thought to be involved in functions such as regulation of appetite and anxiety, and BIBP-3226 has anxiogenic and anorectic effects, as well as blocking the Y 1-mediated corticotropin releasing hormone release.
• Cushing's disease refers only to hypercortisolism secondary to excess production of ACTH from a corticotroph pituitary adenoma ( secondary hypercortisolism / hypercorticism ) or due to excess production of hypothalamus CRH ( Corticotropin releasing hormone ) ( tertiary hypercortisolism / hypercorticism ).
• Deficiency of ACTH is a sign of secondary adrenal insufficiency ( suppressed production of ACTH due to a impairment of the pituitary gland or hypothalamus, cf . hypopituitarism ) or tertiary adrenal insufficiency ( disease of the hypothalamus, with a decrease in the release of corticotropin releasing hormone CRH ).
• A new model has recently surfaced in the literature regarding the HPA axis ( structures in the brain that get activated in response to stress ) and its involvement with dysthymia ( e . g . phenotypic variations of corticotropin releasing hormone ( CRH ) and arginine vasopressin ( AVP ), and down-regulation of adrenal functioning ) as well as forebrain serotonergic mechanisms.
• :This source has : " The principal components of the stress response consist of the hypothalamic-pituitary-adrenal ( HPA ) system ( most commonly known as the HPA axis ), the locus coeruleus-norepinephrine ( "'LC-NE "') system, and the extrahypothalamic corticotropin releasing hormone ( CRH ) system . "-- talk ) 18 : 04, 5 March 2009 ( UTC)