follicular dendritic cells การใช้

• CD19 is expressed on follicular dendritic cells and B cells.
• At the time of the follicular dendritic cell sarcoma discovery information on the effect of chemotherapy and radiation on it was nonexistent.
• Autoreactive B cells, maturated coincidentally, normally do not receive survival signals by antigen planted on follicular dendritic cells and perish by apoptosis.
• The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, hyalocytes, and splenic follicular dendritic cells.
• In addition, CD137 expression is found on dendritic cells, B cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation.
• Small antigens sometimes encounter B cells after diffusing on their own to lymph nodes, but larger pieces of intact antigen appear to be presented to B cells by follicular dendritic cells and macrophages.
• CR1, a surface protein produced primarily by follicular dendritic cells, appears to be critical for generation of appropriately activated B cells of the germinal centre and for mature antibody responses to bacterial infection.
• Also, apoptotic chromatin and nuclei may attach to the surfaces of follicular dendritic cells and make this material available for activating other B cells that may have randomly acquired self-specificity through somatic hypermutation.
• By contrast, follicular dendritic cells ( FDC ) are probably of mesenchymal rather than hematopoietic origin and do not express MHC class II, but are so named because they are located in lymphoid follicles and have long " dendritic " processes.