loop diuretic การใช้

• Metolazone is frequently prescribed in addition to the loop diuretic.
• Loop diuretics such as furosemide ( Lasix ) act on this protein.
• By contrast, loop diuretics promote a significant increase in calcium excretion.
• Treatment is based on medication, including ACE inhibitors, loop diuretics, and phosphodiesterase inhibitors.
• Metolazone and a loop diuretic will synergistically enhance diuresis over the use of either agent alone.
• Inhibition of NKCC1, as with furosemide or other loop diuretics, can result in deafness.
• NSAIDs block the COX pathway that synthesizes prostaglandins, so NSAIDs can reduce the efficacy of loop diuretics.
• Bendroflumethiazide has a role in the treatment of mild heart failure although loop diuretics are better for reducing overload.
• Ototoxicity ( damage to the ear ) is a serious, but rare ADR associated with use of loop diuretics.
• These loop diuretics may be combined with thiazide diuretics such as oral metolazone or intravenous chlorthiazide for a synergistic effect.
• Transport by the encoded protein is inhibited by four loop diuretics, nateglinide, thiazides, probenecid, and glibenclamide.
• The loss of magnesium as a result of loop diuretics has also been suggested as a possible cause of pseudogout ( chondrocalcinosis)
• Unlike loop diuretics, chlortalidone efficacy is diminished in patients with certain renal diseases ( e . g . chronic renal disease ).
• Compared with other loop diuretics, torasemide has a more prolonged diuretic effect than equipotent doses of furosemide and relatively decreased potassium loss.
• A secondary effect of loop diuretics is to increase the production of prostaglandins, which results in vasodilation and increased blood supply to the kidney.
• Unlike the other loop diuretics, etacrynic acid is not a sulfonamide and thus, its use is not contraindicated in those with sulfa allergies.
• "' Azosemide "'is a high-ceiling loop diuretic agent that was brought to market in 1981 by Boehringer Mannheim.
• If a person is outside of the critical phase, a loop diuretic such as furosemide may be used to eliminate excess fluid from the circulation.
• Loop diuretics may also precipitate kidney failure in patients concurrently taking an NSAID and an ACE inhibitor the so-called " triple whammy " effect.
• Lithium-induced nephrogenic DI may be effectively managed with the administration of amiloride, a potassium-sparing diuretic often used in conjunction with thiazide or loop diuretics.