poly adp ribose การใช้

• "' Adenosine diphosphate ribose "'is an ester molecule formed into chains by the enzyme poly ADP ribose polymerase.
• Poly ADP ribose polymerase ( PARP ) inhibitors are another possible treatment, with carriers of BRCA1 / 2 mutations being the most responsive
• Once initiated caspase-9 goes on to cleave procaspase-7, which cleave several cellular targets, including poly ADP ribose polymerase.
• Poly ADP ribose polymerase ( PARP ) inhibitors are another possible treatment, with carriers of BRCA1 / 2 mutations being the most responsive.
• Further support for the theory that DNA damage is the primary cause of aging comes from study of Poly ADP ribose polymerases ( PARPs ).
• Lymphoblastoid cell lines established from blood samples of centenarians have significantly higher activity of the DNA repair protein PARP ( Poly ADP ribose polymerase ) than cell lines from younger ( 20 to 70 year old ) individuals.
• Although studies in murine myeloid precursor cell lines indicated YPEL3 to have a role in apoptosis, human YPEL3 failed to demonstrate an apoptotic response using sub-G1 or poly ADP ribose polymerase cleavage as accepted indicators of programmed cell death.
• "' Talazoparib "'( "'BMN-673 "') is an orally available poly ADP ribose polymerase ( PARP ) inhibitor currently in development by Medivation for the treatment of advanced breast cancer patients with germline BRCA mutations.
• These caspases then activate the effector caspases 3, 6, and 7, leading to cleavage of death substrates such as lamin A, lamin B1, lamin B2, PARP ( poly ADP ribose polymerase ), and DNAPK ( DNA-activated protein kinase ).