isoprostanes การใช้

The authors suggested that measurement of isoprostanes might be a better indication of lipid peroxidation and oxidative damage to DNA.
Biosynthesis of oxylipins is initiated by dioxygenases or monooxygenases; however also non-enzymatic autoxidative processes contribute to oxylipin formation ( phytoprostanes, isoprostanes ).
Similar attacks on arachidonic acid produce a far larger set of products including various isoprostanes, hydroperoxy-and hydroxy-eicosatetraenoates, and 4-hydroxyalkenals.
This along with the finding of increased F2-isoprostanes levels found in blood, urine and cerebrospinal fluid indicate increased damage to lipids and DNA in depressed patients.
The new federal project will also likely test spinal fluid for declining levels of a form of beta-amyloid and for rising levels of isoprostanes, which indicate the level of damage to fats and fat-like compounds in the body, according to Dr . Christopher Clark, an associate professor of neurology at the University of Pennsylvania.