isoprostanes การใช้

• The authors suggested that measurement of isoprostanes might be a better indication of lipid peroxidation and oxidative damage to DNA.
• Biosynthesis of oxylipins is initiated by dioxygenases or monooxygenases; however also non-enzymatic autoxidative processes contribute to oxylipin formation ( phytoprostanes, isoprostanes ).
• Similar attacks on arachidonic acid produce a far larger set of products including various isoprostanes, hydroperoxy-and hydroxy-eicosatetraenoates, and 4-hydroxyalkenals.
• This along with the finding of increased F2-isoprostanes levels found in blood, urine and cerebrospinal fluid indicate increased damage to lipids and DNA in depressed patients.
• The new federal project will also likely test spinal fluid for declining levels of a form of beta-amyloid and for rising levels of isoprostanes, which indicate the level of damage to fats and fat-like compounds in the body, according to Dr . Christopher Clark, an associate professor of neurology at the University of Pennsylvania.