periplocin การใช้

For instance, pharmacological drug therapy with Periplocin in the treatment of rheumatoid arthritis, is also found to inhibit lung cancer in both in-vivo and in-vitro experimental models.
Thus, the proteasome subunit beta type-6 ( PSMB6 ) appears to have a significant role in molecular mechanisms underlying the anti-cancer effects of periplocin on lung cancer cells.
Using immunoblot analysis followed by STRING bioinformatics analysis, it was revealed that Periplocin can inhibited growth of lung cancer by down-regulating proteins, such as ATP5A1, EIF5A, ALDH1 and PSMB6.
Accordingly, the protein profile changes of human lung cancer cell lines A549 in response to periplocin treatment were investigated using proteomics approaches ( 2-DE combined ] with MS / MS ) in conduction with Western blot analysis to verify the changed proteins.