periplocin การใช้

• For instance, pharmacological drug therapy with Periplocin in the treatment of rheumatoid arthritis, is also found to inhibit lung cancer in both in-vivo and in-vitro experimental models.
• Thus, the proteasome subunit beta type-6 ( PSMB6 ) appears to have a significant role in molecular mechanisms underlying the anti-cancer effects of periplocin on lung cancer cells.
• Using immunoblot analysis followed by STRING bioinformatics analysis, it was revealed that Periplocin can inhibited growth of lung cancer by down-regulating proteins, such as ATP5A1, EIF5A, ALDH1 and PSMB6.
• Accordingly, the protein profile changes of human lung cancer cell lines A549 in response to periplocin treatment were investigated using proteomics approaches ( 2-DE combined ] with MS / MS ) in conduction with Western blot analysis to verify the changed proteins.