phosphogluconate การใช้

6-Phosphogluconate dehydrogenase deficiency can be asymptomatic in many patients who are carriers.
Recently, phosphogluconate dehydrogenase has been posited as a potential drug target for African sleeping sickness ( trypanosomiasis ).
It is formed by 6-phosphogluconolactonase, and acted upon by phosphogluconate dehydrogenase to produce ribulose 5-phosphate.
High levels of NADPH are believed to inhibit the enzyme, while 6-phosphogluconate acts to activate the enzyme.
Structural differences between mammalian and trypanosome 6-phosphogluconate dehydrogenase have allowed for the development of selective inhibitors of the enzyme.