phosphogluconate การใช้

• 6-Phosphogluconate dehydrogenase deficiency can be asymptomatic in many patients who are carriers.
• Recently, phosphogluconate dehydrogenase has been posited as a potential drug target for African sleeping sickness ( trypanosomiasis ).
• It is formed by 6-phosphogluconolactonase, and acted upon by phosphogluconate dehydrogenase to produce ribulose 5-phosphate.
• High levels of NADPH are believed to inhibit the enzyme, while 6-phosphogluconate acts to activate the enzyme.
• Structural differences between mammalian and trypanosome 6-phosphogluconate dehydrogenase have allowed for the development of selective inhibitors of the enzyme.
• It may also be acted upon by 6-phosphogluconate dehydratase to produce 2-keto-3-deoxy-6-phosphogluconate.
• It may also be acted upon by 6-phosphogluconate dehydratase to produce 2-keto-3-deoxy-6-phosphogluconate.
• The general structure, as well as several critical residues, on 6-phosphogluconate dehydrogenase appear to be well conserved over various species.
• One mole of glucose-6-phosphate is initially dehydrogenated to 6-phosphogluconate and subsequently decarboxylated to yield one mole of CO 2.
• The lack of synthesis of a specific protein on chromosome 1 has reduced a subject suffering from 6PGD deficiency from producing adequate amounts of the 6-Phosphogluconate dehydrogenase enzyme.
• Pentose Phosphate Pathway with a breakdown in the conversion of 6-Phosphogluconate dehydrogenase to Ribulose-5-phosphate due to a deficiency of 6-Phosphogluconate Dehydrogenase enzyme.
• Pentose Phosphate Pathway with a breakdown in the conversion of 6-Phosphogluconate dehydrogenase to Ribulose-5-phosphate due to a deficiency of 6-Phosphogluconate Dehydrogenase enzyme.
• Since NADPH is required by both thioredoxin reductase and glutathione reductase to reduce oxidized thioredoxin and glutathionine, 6-phosphogluconate dehydrogenase is believed to be involved in protecting cells from oxidative damage.
• 6-phosphogluconate dehydrogenase is involved in the production of ribulose 5-phosphate, which is used in nucleotide synthesis, and functions in the pentose phosphate pathway as the main generator of cellular NADPH.
• "Penicillium chrysogenum " has been used industrially to produce penicillin and xanthocillin X, to treat pulp mill waste, and to produce the enzymes polyamine oxidase, phosphogluconate dehydrogenase, and glucose oxidase.
• Lysine Residue 133 serves as the nucleophile and attacks the carbonyl group of 2-Keto-3-deoxy-6-phosphogluconate to form a protonated carbinolamine intermediate, also known as a Schiff base intermediate.
• 6-phosphogluconate dehydrogenase ( 6PGD ) deficiency has similar symptoms and is often mistaken for G6PD deficiency, as the affected enzyme is within the same pathway, however these diseases are not linked and can be found within the same patient.
• One of the reactions KDPG Aldolase catalyzes, as in the Entner Doudoroff pathway, is the reversible cleavage of 2-keto-3-deoxy-6-phosphogluconate ( KDPG ) into pyruvate and D-glyceraldehyde-3-phosphate.
• The conversion of 6-phosphogluconate and NADP to ribulose 5-phosphate, carbon dioxide, and NADPH is believed to follow a sequential mechanism with ordered product release . 6-phosphogluconate is first oxidized to 3-keto-6-phosphogluconate and NADPH is formed and released.
• The conversion of 6-phosphogluconate and NADP to ribulose 5-phosphate, carbon dioxide, and NADPH is believed to follow a sequential mechanism with ordered product release . 6-phosphogluconate is first oxidized to 3-keto-6-phosphogluconate and NADPH is formed and released.