acetoacetate การใช้

• Acetoacetate decarboxylase is a 365 kDa complex with a homododecameric structure.
• Beta-diketones appear to inhibit acetoacetate decarboxylase well but slowly.
• Geuther is best known for his discovery of ethyl acetoacetate.
• In alcoholic solution it condenses with sodium acetoacetate to form 4-methylumbelliferone.
• Acetoacetate decarboxylase is inhibited by a number of compounds.
• The smell of acetoacetate and / or acetone in breath is a common feature in ketosis.
• This conversion is one of many steps in breaking L-tyrosine into acetoacetate and fumarate.
• Addition of free cysteine to the inhibited enzyme is able to reverse CMS inhibition of acetoacetate decarboxylase.
• This elevated beta-hydroxybutyrate level is naturally expected, as beta-hydroxybutyrate is formed from acetoacetate.
• Under elevated levels of acetoacetate and D-?-hydroxybutyrate, acetoacetate decarboxylase produces significantly more acetone.
• Under elevated levels of acetoacetate and D-?-hydroxybutyrate, acetoacetate decarboxylase produces significantly more acetone.
• The ketone bodies are possibly anticonvulsant in themselves; in animal models, acetoacetate and acetone protect against seizures.
• Acetoacetate and D-?-hydroxybutyrate freely interconvert through the action of D-?-hydroxybutyrate dehydrogenase.
• The experimental work of his and others yielded puzzling results and induced debates on the nature of ethyl acetoacetate.
• Hantzsch pyridine synthesis with acetoacetate, formaldehyde and ammonium acetate, and iron ( III ) chloride as the catalyst.
• Aldol condensation of acetone and ethyl acetoacetate gave ?-keto-ester "'3 " '.
• Figure 1 : General mechanism of acetoacetate decarboxylase, proceeding through a Schiff base intermediate and producing acetone and carbon dioxide
• Ethyl acetoacetate, a important starting material in organic synthesis, can be prepared using a diketene in reaction with ethanol.
• Thereby fumarate ( also a metabolite of the citric acid cycle ) and acetoacetate ( 3-ketobutyroate ) are liberated.
• Ketone bodies that commonly appear in the urine when fats are burned for energy are acetoacetate and beta-hydroxybutyric acid.