airn การใช้

• Airn is an lncRNA used to silence Igf2r and other surrounding genes.
• The lncRNA Airn is an lncRNA that regulates Igf2r expression.
• Airn is silenced in the maternal allele through Igf2r transcription.
• In the brain, however, Igf2r alleles are both expressed due to Airn mediation being repressed in neuronal cells.
• Smith records that the'Airn Yett'of the old castle was still preserved and its details published ( see Wikimedia ).
• Airn acts by cis-acting silencing of the Igf2r region through overlapping the Igf2r gene through the antisense transcript encoded by Airn.
• Airn acts by cis-acting silencing of the Igf2r region through overlapping the Igf2r gene through the antisense transcript encoded by Airn.
• This mechanism is very efficient in that Igf2r is silenced by transcription of Airn, while the RNA product silences other genes near Igf2r.
• This lncRNA is an RNA modified by imprinting, leading to Airn expression in the paternal allele, but not in the maternal allele.
• In the mechanism to silence Igf2r, the transcription of the lncRNA Airn silences the expression of Igf2r, as opposed to an active repression mechanism.
• His commentary is spiced with the occasional English word to clue in the viewer to what he is attempting; for example, " Aweenda shmure da froog's legs " or " Yur puurt thuur chiir-ken airn der bewl ".
• Airn is the antisense gene of Ifg2r, so if Airn is being transcribed, the transcriptional machinery may cover a part of or the entire promoter region of Igf2r, so RNA polymerase cannot bind to the promoter region of Igf2r in order to initiate transcription.
• Airn is the antisense gene of Ifg2r, so if Airn is being transcribed, the transcriptional machinery may cover a part of or the entire promoter region of Igf2r, so RNA polymerase cannot bind to the promoter region of Igf2r in order to initiate transcription.
• The imprinting mechanisms described above work on the chromosome that the Airn lncRNA is produced, but there are many other imprinted genes that work to silence genes on other chromosomes or to silence the similar allele ( s ) on the opposing chromosome of the same pair.