aldolase การใช้

• Aldolase A deficiency has been associated with myopathy and hemolytic anemia.
• In bacterial systems, sialic acids are biosynthesized by an aldolase enzyme.
• Aldolase B converts it into glyceraldehyde and dihydroxyacetone phosphate ( DHAP ).
• This cleavage is very similar mechanistically to the aldolase A reaction of glycolysis.
• In lymphocytes, ALDOA is the predominant aldolase isoform.
• The active site of this archaeal aldolase is also in a TIM barrel.
• Aldolase is divided into two classes by mechanism.
• Each subunit contains a phosphate-ion bound in position of the aldolase biding site.
• Genetic mutations leading to defects in aldolase B result in a condition called hereditary fructose intolerance.
• This is the same mechanism proposed by Barbas for aldolase antibodies reported by the group in 1995:
• Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle.
• In mammalian aldolase, the key catalytic amino acid residues involved in the reaction are lysine and tyrosine.
• Compromised immunity has also been indicated, relating to the predominance or exclusivity of aldolase A in leukocytes.
• Characterised as a recessive disorder, symptomatic presentation requires the inheritance of aldolase A mutations from both parents.
• In particular this leads to a complication for clearly delineating the effects of enzymatic aldolase-A deficiency.
• However, unlike in the primary instance parental aldolase activity was also partially reduced without significant physiological ailment.
• In particular neurological impairment was conjecturally linked with the predominant role of aldolase A in the brain during development.
• KDPG Aldolase was recently determined to be a trimer through crystallographic three-fold symmetry, with 225 residues.
• Another part of the explanation was the presumed complexity of aldolase catalysis that dominated chemical thinking for a long time.
• Plants and algae have plastidal aldolase, sometimes a relic of endosymbiosis, in addition to the usual cytosolic aldolase.