amidine การใช้

• This enzyme belongs to the family of lyases, specifically amidine lyases.
• The simplest amidine is formamidine, HC ( = NH ) NH 2.
• It is an amidine base used in organic synthesis.
• The structure of bottromycin contains a macrocyclic amidine as well as a thiazole ring.
• To obtain the final product macrocycle, macrolactamization of the amidine-containing intermediate was required.
• The oxoacid from which an amidine is derived must be of the form R " n"
• It binds free amino groups at pH range 7.0-10.0 to form amidine bonds.
• "' Phenamidine "'is an antiprotozoal drug of the amidine class used in veterinary medicine.
• Bottromycin has a unique structure, consisting of the macrocyclic amidine linkage and four ?-methylated amino acids.
• Carboxamidines are frequently referred to simply as amidines, as they are the most commonly encountered type of amidine in organic chemistry.
• Strong and hindered non-nucleophilic guanidine bases are accessible from tetramethylurea in a simple manner, which are in contrast to the fused amidine bases DBU not alkylated.
• The structure was confirmed in the 1980s and 1990s to be a cyclic iminopeptide based on NMR studies, with a linear side chain connected to the macrocycle via an amidine linkage.
• These salts can react with an excess of alcohol to form the orthoester RC ( OR ) 3, with ammonia or an amine to form an amidine or with water to form an ester.
• To obtain the amidine linkage, a tripeptide intermediate was coupled to a phthaloyl-protected thioamide via mercury-mediated condensation using mercury ( II ) trifluoromethanesulfonate ( Hg ( OTf ) 2 ) to yield a branched amidine intermediate.
• To obtain the amidine linkage, a tripeptide intermediate was coupled to a phthaloyl-protected thioamide via mercury-mediated condensation using mercury ( II ) trifluoromethanesulfonate ( Hg ( OTf ) 2 ) to yield a branched amidine intermediate.
• In addition, a salt bridge between Glu-97 of thrombin and the amidine group fixed in the pyrrolidine ring of DX-9065a reduces the flexibility of the DX-9065a molecule, which now cannot rotate enough to avoid the electrostatic clash.