aminotransferases การใช้

• In bacteria, the ammonia is assimilated to amino acids via glutamate and aminotransferases.
• The two common types of aminotransferases are Alanine aminotransferase ( ALT ) and Aspartate aminotransferase ( AST ).
• In addition, PLP is used by aminotransferases ( or transaminases ) that act upon unusual sugars such as perosamine and desosamine.
• These include proteases, sporulation proteins, amino acid aminotransferases, amino acid and oxo acid oxidoreductases, and amino acid tRNA synthetases.
• The structure of the OAT protein has been resolved usign X-ray cyrstallography and shows similarity to other subgroup 2 aminotransferases such as dialkyglucine decarboxylatse.
• Elevated blood serum GLDH levels indicate liver damage and GLDH plays an important role in the differential diagnosis of liver disease, especially in combination with aminotransferases.
• Transamination in biochemistry is accomplished by enzymes called transaminases or aminotransferases . ?-ketoglutarate acts as the predominant aminogroup acceptor and produces glutamate as the new amino acid.
• The biological function of branched chain aminotransferases ( BCAT ) is to catalyse the synthesis or degradation of the branched chain amino acids leucine, isoleucine, and valine.
• GLDH is important for distinguishing between acute viral hepatitis and acute toxic liver necrosis or acute hypoxic liver disease, particularly in the case of liver damage with very high aminotransferases.
• ALT ( and all aminotransferases ) require the coenzyme pyridoxal phosphate, which is converted into pyridoxamine in the first phase of the reaction, when an amino acid is converted into a keto acid.
• Accumulation of amyloids in the liver can lead to elevations in serum aminotransferases and alkaline phosphatase, two biomarkers of liver injury, which is seen in about one third of people . sprue-like picture.
• Usually, these changes reflect a cholestatic pattern and include raised levels of alkaline phosphatase ( which is the most common liver function test anomaly seen in persons with sarcoidosis ), while bilirubin and aminotransferases are only mildly elevated.
• Some bone and heart disorders can lead to an increase in ALP and the aminotransferases, so the first step in differentiating these from liver problems is to compare the levels of GGT, which will only be elevated in liver-specific conditions.