angiostatin การใช้

• We are confident that the angiostatin molecule can reduce tumors in mice.
• The other substance developed by Folkman and his colleagues is called angiostatin.
• But exactly how angiostatin and similar compounds work has not been known.
• Angiomotin p80 locates and binds angiostatin on the cell surface.
• Angiomotin p130 does not promote cell migration, nor responds to angiostatin.
• But, Kerbel said, angiostatin and endostatin do not act on tumors.
• Then the researchers combined injections of angiostatin in low doses with radiation therapy.
• Hence angiostatin might be expected to deprive radiation of any targets at all.
• Both endostatin and angiostatin work against tumor blood vessels.
• Endostatin and angiostatin are fragments of larger proteins made naturally in the body.
• Folkman checked to see the treatment : angiostatin.
• The angiostatin used in the experiments was made at Northwestern University, said Weichselbaum.
• Angiostatin is thought to work by inhibiting the growth and division of endothelial cells.
• We have confidence in the principle of angiostatin,
• Angiostatin is more difficult to make than endostatin.
• Much of the angiostatin was inactive because its structure is so hard to duplicate.
• Angiostatin is part of a larger protein called plasminogen, which helps blood clot.
• Meanwhile, early tests of endostatin and angiostatin in cancer patients have dampened enthusiasm.
• Angiostatin therefore, is an inhibitor of angiomotin.
• All 10 of the mice that had been injected with angiostatin were free of cancer.