ankyrins การใช้

• The most important binding partners of the cytoplasmic tail of L1 proteins are ankyrins.
• Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains.
• The protein encoded by this gene, ankyrin-3 is an immunologically distinct gene product from ankyrins ANK1 and ANK2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems.
• Most ankyrins are typically composed of three structural domains : an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation.
• L1 family members bind to many cytoplasmic proteins such as Ankyrins, ezrin-moesin-radixin ( ERM ) proteins, signaling molecules like src ( src gene ) and erk ( Extracellular signal-regulated kinases ) and proteins important in trafficking, such as AP-2.