anticodon การใช้

• In translation, complementary tRNA anticodon sequences to mRNA codons.
• The ribosome must discriminate between correct and incorrect codon-anticodon pairs.
• An interesting example of A-minor is its role in anticodon recognition.
• Cytoplasmic tRNA genes can be grouped into 49 families according to their anticodon features.
• The reason is that the ribosome only sees the anticodon of the tRNA during translation.
• The tRNA anticodon domain associates with the mRNA codon domain in the ribosomal A site.
• This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA.
• It is complementary to the anticodon of the tRNA that is a substrate of the tRNA synthetase under regulation.
• Thus, the ribosome will not be able to discriminate between tRNAs with the same anticodon but linked to different amino acids.
• Aminoacyl tRNA synthetases ( enzymes ) catalyze the bonding between specific tRNAs and the amino acids that their anticodon sequences call for.
• Codon is recognized by pairing with the anticodon, and by additional interaction with the " decoding center " of the ribosome.
• The specificity of the amino acid activation is as critical for the translational accuracy as the correct matching of the codon with the anticodon.
• Queuine is involved in the anticodon sequence of certain wobble position in the tRNA of Asparagine, Aspartic acid, Histidine, and Tyrosine.
• Recognition of the appropriate tRNA by the synthetases is not mediated solely by the anticodon, and the acceptor stem often plays a prominent role.
• It also revealed differences from tRNA : the anticodon arm is missing in tmRNA, and the D arm region is a loop without base pairs.
• The yeast guanylyl transferase specific to tRNA His is unique in being the only known non-tRNA synthetase enzyme that specifically recognizes the tRNA anticodon.
• If the codon-anticodon pairing is correct, EF-Tu hydrolyzes guanosine triphosphate ( GTP ) into guanosine diphosphate ( GDP ) and inorganic phosphate.
• It has sites for amino acid attachment and an anticodon region for codon recognition that binds to a specific sequence on the messenger RNA chain through hydrogen bonding.
• Following initiation, the polypeptide chain is extended via anticodon : codon interactions, with the ribosome adding amino acids to the polypeptide chain one at a time.
• All of the currently sequenced euryarchaeal and crenarchaeal genomes contain only one annotated isoleucine tRNA and three tRNAs with the CAU anticodon ( annotated as methionine tRNAs ).