apoa การใช้

• Rights to ApoA-1 Milano were acquired in 2003 by Pfizer.
• Currently, no drugs based on ApoA-1 Milano are commercially available.
• ApoA-1, the good cholesterol protein, seemed to protect against heart attacks.
• Exchangeable apolipoproteins ( apoA, apoC and apoE ) have the same gene cluster on chromosome 11.
• TDP-43 was originally identified as a transcriptional repressor that binds to chromosomally integrated apoA-II gene.
• The ApoA-1 Milano Trial, published in JAMA in 2003, was the first published placebo controlled, 2 dose level, trial in humans.
• The protein components of TLF-1 are haptoglobin related protein ( HPR ), apolipoprotein L-1 ( apoL-1 ) and apolipoprotein A-1 ( apoA-1 ).
• In the 1990s, researchers at the Cedars-Sinai Medical Center showed that injection of a synthetic version of the mutant ApoA-1 into rabbits and mice could reverse vascular plaque buildup.
• In particular, TDP-43 is a splicing factor binding to the intron8 / exon9 junction of the CFTR gene and to the intron2 / exon3 region of the apoA-II gene.
• Apolipoprotein A-1, or apoA-1, is the protein part of HDL, the good cholesterol, while apolipoprotein B, or apoB is the protein in LDL, the bad cholesterol.
• The study has also been able to show direct effects on the beta chain of ATP synthase ( 5 ) and on production ( 6 ) and hepatic uptake ( 7 ) of apoA-I also increase HDL cholesterol levels.
• However, over the course of the project they produced only enough ApoA-1 Milano to partially treat thirty out of the forty-five people in the randomized trial, giving them one weekly dose each for five weeks.
• They are typically composed of 80-100 proteins per particle ( organized by one, two or three ApoA; more as the particles enlarge picking up and carrying more fat molecules ) and transporting up to hundreds of fat molecules per particle.
• Hot melt adhesives can be water or solvent based and may consist of various raw materials including EVA, PUR, PA, APOA, and PO . A substrate primer may also be used as a bonding agent between the adhesive and the substrate.
• In 2003 Nissen led a " Journal of the American Medical Association " study, producing evidence that five weekly infusions of ApoA-I Milano / phospholipids complex, a synthetic form of HDL, can possibly remove significant amounts of plaque from coronary arteries.
• "' ApoA-1 Milano "'is a naturally occurring mutant of apo A1, found in a few families in Limone sul Garda, Italy, and, by genetic + church record family tree detective work, traced to a single individual in the 18th century.
• During the acute-phase response, elevated levels of SAA1 in the plasma displaces ApoA-I and becomes a major apolipoprotein of HDL . The exact biological consequence of HDL remodeling by SAA1 is still under investigation, using recently developed tools such as the Saa1 and Saa2 knockout mice.
• Men who had the highest levels of apoB, the bad protein, combined with the lowest levels of apoA-1, the good protein, were nearly four times more likely to suffer a fatal heart attack than those who had the lowest concentrations of the bad protein and the highest of the good protein.
• "This is perhaps the largest study to date demonstrating that the ratio of apoB to apoA-1 may offer better predictive value for the development of coronary disease than most other data we commonly track, " said Dr . David A . Meyerson, a Johns Hopkins University cardiologist and American Heart Association expert who was not connected with the study.