aptamer การใช้

• Peptide aptamer scaffolds are typically small, ordered, soluble proteins.
• A DNA aptamer inhibitor of Autotaxin has also been described.
• Structure of the M-box riboswitch aptamer domain from Bacillus subtilis.
• AptaBiD or Aptamer-Facilitated Biomarker Discovery is a technology for biomarker discovery.
• The x-ray crystal structure of the TPP riboswitch aptamer has been solved.
• He isolated the first aptamer ( term he used for the first time ).
• Riboswitches are often conceptually divided into two parts : an aptamer and an expression platform.
• An example is a tenascin-binding aptamer under development by Schering AG for cancer imaging.
• Adding an unnatural base to a standard aptamer can increase its ability bind to target molecules.
• Glycine riboswitches usually consist of two metabolite-binding aptamer domains with similar structures in tandem.
• Only few hydrophobic unnatural base as a fifth base significantly augment the aptamer affinity to target proteins.
• The Adenine Riboswitch selectively recognizes adenine, and contains a uracil ribonucleotide in position 74 of the adenine-binding aptamer domain.
• The Guanine Riboswitch selectively recognizes guanine, and contains a cytosine ribonucleotide in position 74 of the guanine-binding aptamer domain.
• The aptamer directly binds the small molecule, and the expression platform undergoes structural changes in response to the changes in the aptamer.
• The aptamer directly binds the small molecule, and the expression platform undergoes structural changes in response to the changes in the aptamer.
• The core of malachite green aptamer is also a kind of base quadruplex with a different hydrogen bonding pattern ( See Figure ).
• In addition, the company NeoVentures Biotechnology Inc . has successfully commercialized the first aptamer based diagnostic platform for analysis of mycotoxins in grain.
• In the absence of adenine, the aptamer domain of the riboswitch instead associates with the riboswitch expression platform, leading to transcription termination.