arginase การใช้

• It is characterized by lowered activity of arginase in hepatic cells.
• Arginase catalyzes the hydrolysis of arginine to ornithine and urea.
• Arginase transcript variants encoding different isoforms have been found for this gene.
• Specifically, arginase converts L-arginine into L-ornithine and urea.
• Mammalian arginase is active as a trimer, but some bacterial arginases are hexameric.
• Arginase's active site is extraordinarily specific.
• Arginase deficiency, unlike other urea cycle disorders, does not entirely prevent ureagenesis.
• There are several arginase isozymes that differ in catalytic, molecular and immunological properties.
• Ammonia and arginine are thought to cause neurological problems and other symptoms of arginase deficiency.
• Arginase is about the enzyme reaction and has links back to both ARG1 and ARG2.
• Arginase deficiency typically refers to decreased function of arginase I, the liver isoform of arginase.
• Arginase deficiency typically refers to decreased function of arginase I, the liver isoform of arginase.
• Arginase deficiency typically refers to decreased function of arginase I, the liver isoform of arginase.
• Arginase is a binuclear manganese metallopritein that catalyse the hydrolysis of L-arginine to L-ornithine and urea.
• The ureohydrolase superfamily includes arginase ( ), agmatinase ( ), formiminoglutamase ( ) and proclavaminate amidinohydrolase ( ).
• The second isozyme, Arginase II, has been implicated in the regulation of the arginine / ornithine concentrations in the cell.
• N-hydroxy-L-arginine ( NOHA ), an intermediate of NO biosynthesis, is a moderate inhibitor of arginase.
• Release of arginase, proline, polyaminases and TGF-? by the activated M2 cell is tied with wound repair and fibrosis.
• Arginase is used to decrease the arginine levels in blood serum in order to starving the cancer cells that are auxotrophic to arginine aminoacid.
• The evidence of boronic acid mimic as transitions state analogue inhibitor was elucidated by x-ray crystal structure complex with human arginase I.