astemizole การใช้

• Astemizole does also act as FIASMA ( functional inhibitor of acid sphingomyelinase ).
• Astemizole was discovered by Janssen Pharmaceutica in 1977.
• Erythromycin has been reported to significantly alter the metabolism of the nonsedating antihistamines terfernadine and astemizole when taken concomitantly.
• Hismanal, known by the generic name astemizole, first received approval from the Food and Drug Administration in 1988.
• These include Seldane ( terfenadine ), Hismanal ( astemizole ) and Claritin ( loratadine ), all of them tablets.
• Seldane ( terfenadine ), manufactured by Marion Merrell Dow, had been approved the year before, and Hismanal ( astemizole ) was already under FDA review.
• Astemizole is rapidly absorbed from the gastrointestinal tract and competitively binds to histamine H 1 receptor sites in the gastrointestinal tract, uterus, blood vessels, and bronchial muscle.
• Despite some earlier reports that astemizole does not cross the blood brain barrier, several studies have shown high permeability and high binding to protein folds associated with Alzheimer's.
• "' Astemizole "'( marketed under the brand name "'Hismanal "', developmental code R43512 ) was a second-generation antihistamine drug that has a long duration of action.
• In a 2013 paper published in the Proceedings of the National Academy of Sciences, scientists from The Scripps Research Institute reported that Astemizole, a medication approved for human use, has been found to have anti-prion activity and may lead to a treatment for Creutzfeldt Jakob disease.