autophagy การใช้

• Mechanical injury to cartilage explants in culture also reduced autophagy proteins.
• This data supports the development of therapies that will encourage autophagy.
• Induced autophagy interfers with the action of the chemotherapy drug vincristine.
• Knockdown of the PSMB7 gene may also induce autophagy in cardiomyocytes.
• This inhibits autophagy, the major degradation pathway in eukaryotic cells.
• Autophagy allows the orderly degradation and recycling of cellular components.
• The first Keystone Symposia on autophagy was held in 2007 at Monterey.
• In both cases, autophagy is observed to markedly increase.
• Moreover, active mTOR supports tumor growth also indirectly by inhibiting autophagy.
• Sorafenib treatment induces autophagy, which may suppress tumor growth.
• LRRK2 is also a substrate for chaperone-mediated autophagy.
• GATA4 is regulated through the autophagy-lysosome pathway in eukaryotic cells.
• Noncovalent interactions are important for its cargo targeting functions in selective autophagy.
• In fact an overabundance of APOL1 within a cell results in autophagy.
• ATG16L1 is a component of a large protein complex essential for autophagy.
• Atg32 silencing stops recruitment of autophagy machinery and mitochondrial degradation.
• Hypoxia, in turn, drives oxidative stress and autophagy.
• Strong induction of apoptosis and autophagy has also been seen.
• Moreover, mTORC2 activity has been implicated in the regulation of autophagy.
• Tumor cells are killed viva autophagy, rather than apoptosis.