autoreactive การใช้

• However, the difference lies in the specificity of the autoreactive antibodies in each case.
• In the presence of autoreactive T cells, a chronic autoimmune disease may be the consequence.
• Reduced apoptosis was also implicated in the accumulation of autoreactive B-cells found in the glands.
• Autoreactive B cells can accidentally emerge during somatic hypermutation and migrate into the germinal center light zone.
• Just as in T cells, clonal deletion and clonal anergy can physically eliminate autoreactive B cell clones.
• EFS regulates T-cell function and maturation, preventing expansion of autoreactive clones and pathological immune responses.
• Central tolerance refers to the tolerance established by deleting autoreactive lymphocyte clones before they develop into fully immunocompetent cells.
• Participants who received BCG vaccination also experienced a transient increase in the number of circulating dead autoreactive T cells against insulin.
• Autoreactive T cells must normally be held in check by the suppressive environment produced by microglia and dendritic cells in the eye.
• The T cells recognize myelin as foreign and attack it, explaining why these cells are also called " autoreactive lymphocytes ".
• Neurovax is designed to stimulate FOXP3 + regulatory T-cells that can then suppress the autoreactive T-cells in some patients.
• Whether through infection or other causes, this balance can be upset and autoreactive T cells allowed to proliferate and migrate to the eye.
• It can also precipitate autoimmune disease through the suppression of suppressor T cell populations and / or the emergence of autoreactive B-cells.
• Autoreactive B cells, maturated coincidentally, normally do not receive survival signals by antigen planted on follicular dendritic cells and perish by apoptosis.
• Other lectins within the immune system are thought to play a role in self-nonself discrimination and they likely modulate inflammatory and autoreactive processes.
• Weakly autoreactive B cells may also remain in a state of immunological ignorance where they simply do not respond to stimulation of their B cell receptor.
• Autoreactive T cells are activated " de novo " by self epitopes released secondary to pathogen-specific T cell-mediated bystander damage.
• It is hoped that this immune response directed against a specific subset of autoreactive T cells might reduce the number of these autoreactive cells in MS patients.