biguanide การใช้

• Other related compounds were being investigated clinically at this time, including biguanide derivatives.
• "' Phenformin "'is an antidiabetic drug from the biguanide class.
• It is a polymer or oligomer where biguanide functional groups are connected by hexyl hydrocarbon chains, with varying chain lengths.
• In 1929, Slotta and Tschesche discovered its sugar-lowering action in rabbits, finding it the most potent biguanide analog they studied.
• More patients in the Polyhexamethylene biguanide group healed in the 6-month period when compared with the controls-97 % v . 89 %.
• "' Buformin "'( 1-butylbiguanide ) is an oral antidiabetic drug of the biguanide class, chemically related to metformin and phenformin.
• A retrospective analysis of wound cleanser clinical efficacy and cost-effectiveness focussed on Polyhexamethylene biguanide solution, Ringer s solution or saline in 112 venous leg ulcer patients.
• The study group received the Polyhexamethylene biguanide solution ( n = 59 ) and the control group received either Ringer s solution or saline ( n = 53 ).
• Later, working at Laboratoires Aron in Paris, he was prompted by Garcia's report to reinvestigate the blood sugar-lowering activity of metformin and several biguanide analogs.
• Phenformin, another biguanide, was withdrawn from the market because of an increased risk of lactic acidosis ( rate of 40-64 per 100, 000 patient-years ).
• "' Polyaminopropyl biguanide "'( "'PAPB "') is a disinfectant and a preservative used for disinfection on skin and in cleaning solutions for contact lenses.
• Androgen, antiandrogen, gonadotropin, corticosteroid, growth hormone, insulin, antidiabetic ( sulfonylurea, biguanide / metformin, thiazolidinedione, insulin ), thyroid hormones, antithyroid drugs, calcitonin, diphosponate, vasopressin analogues
• The concentration of dissolved proteins was measured and the findings indicate that a surfactant containing solution ( polyhexamethylene biguanide with betaine ) ( Prontosan?) was more effective than saline in removing the protein ( adhered dried plasma or fibrin ).
• The work for Shapiro's doctoral thesis, " Reaction of Phenyl Biguanide with Esters and Related Compounds ", published in JACS in 1954, was performed at the Polytechnic Institute of Brooklyn and in the laboratories of the Arlington Chemical Co . and US Vitamin Corp . under the direction of Prof . Charles G . Overberger.