bryostatin การใช้

• The structure of bryostatin 1 was determined in 1982.
• Bryostatin 1 is a potent modulator of protein kinase C ( PKC ).
• Bryostatin 1 effects on different isoforms of PKC vary.
• Investigations on how bryostatin 1 behaves in a unique fashion are ongoing in several laboratories.
• Bryostatin 1 can act as a PKCe activator and is being investigated for Alzheimer's disease.
• Bryostatin-1, from the bryozoan Bugula neritina, collected off the coast of California, potential cancer drug.
• Naturalists at Arizona State University, a Natural Products Branch grantee, found bryostatin-1 in Bugula neritina about 20 years ago.
• To date 20 different bryostatins have been isolated; further, certain analogs of bryostatin have been referred to as " bryologs ".
• The Keck allylation has also been utilized to form substituted tetrahydropyrans enantioselectively, moieties found in products such as phorboxazole and bryostatin 1.
• In " in vitro " tests bryostatin 1 was able to inhibit cell growth and angiogenesis and to excite cell differentiation and apoptosis.
• Short-term effects of bryostatin 1 include activation of classical or conventional PKCs and novel PKCs, whereas prolonged presence leads to lowered PKC activation.
• The ability of bryostatin 1 to alleviate brain damage in ischaemically brain-injured rats also seems promising and may open another therapeutic field for bryostatins.
• _Bryostatin, made from moss-like animals that live on pier pilings, just became the first marine anticancer product to enter Phase II testing as a possible therapy for deadly melanoma.
• Nobody knows where bryostatin-1 comes from, whether from a stringy little sea creature known as " Bugula neritina " or from bacteria that live in the creature's stringy gut.
• Bryostatin, a drug derived from relatives of Fort Pierce's sandy creatures, is being tested on human volunteers as a possible new class of cancer drug, one that seems to act on particularly stubborn forms of the disease.
• Drug trials aimed at obtaining a Food and Drug Administration license for bryostatin-1 are underway, and a southern California marine biotechnology company, CalBioMarine Inc ., says it has perfected a technique of growing bryozoans by the ton.
• In 1968 GSML provided the first specimens of the bryozoan " Bugula neritina " used by the National Cancer Institute ( NCI ) to develop the bryostatin family of drugs used for treatment of cancer, HIV, Alzheimer s disease and strokes.
• Although contractors working for the National Cancer Institute's Natural Products Branch, which sponsors searches for drugs in obscure plants and marine creatures, have collected and sent in samples of over 60, 000 species for evaluation, only bryostatin-1 and a handful of other potential drugs have been identified.
• BRYOSTATIN _ WASHINGTON _ The presence of a group of single-celled animals called bryozoans in underwater sand just off Fort Pierce, Fla ., didn't matter to anybody until concern about the animals'future caused a federal judge last week to temporarily halt Corps of Engineers work to renourish the beach.
• Mendola said that in addition to developing a technique whereby bryozoans are " seeded " on perforated plastic plates and grown in the ocean, his company is working to identify and transplant the gene for bryostatin-1 in some type of easily grown bacteria in the hope of producing great quantities of the substance.