c1q การใช้

• Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis.
• BaI3 has been shown to have a high affinity for C1q proteins.
• C1q is an important contributor to the clearance of apoptotic cells and debris.
• Strikingly, it has been shown that anti-C1qRp significantly reduced C1q enhanced phagocytosis.
• C1q added to hippocampal neurons expressing BaI3 resulted in a decrease in the number of synapses.
• Opsonins include Mfge8, Gas6, Protein S, antibodies and complement factors C1q and C3b.
• Myonectin is a member of the C1q / TNF-related protein ( CTRP ) family.
• It is a member of the C1Q domain proteins which have important signalling roles in inflammation and in adaptive immunity.
• In the classical pathway C4 binds to Ig-associated C1q and C1r 2 s 2 enzyme cleave C4 to C4b and 4a.
• C4b binds to C1q, antigen-associated Ig ( specifically to its Fc portion ), and even to the microbe surface.
• C1q associates with C1r and C1s in order to yield the C1-complex, the first component of the serum complement system.
• The anti-C1q antibodies found in patients with Hypocomplementemic Urticarial Vasculitis activate C1q, which instigates activation of the entire complement pathway.
• The anti-C1q antibodies found in patients with Hypocomplementemic Urticarial Vasculitis activate C1q, which instigates activation of the entire complement pathway.
• Case studies of individuals with HUV have also highlighted other potential complicating factors which it seems the anti-C1q antibodies play a role in.
• A more recent study confirmed that C1qRp is identical to CD93 protein, but failed to demonstrate a direct interaction between CD93 and C1q under physiological conditions.
• C1q is an integral component within the complement pathway  a complicated cascade of protein interactions, culminating in an immune response against a broad variety of pathogens.
• Another mechanism is direct binding of antibodies to GBM antigens such as C1q, nucleosomal proteins, heparin sulphate or laminin, which can initiate an inflammatory response by activating complement.
• Unfortunately there are no known specific therapies for HUV . The regime of prescription steroids and other immunosuppressive drugs aims to dampen the body s production of anti-C1q antibodies.
• When injected into target tissue encourages recruitment of c1q and activates downstream events, eventually leading to the formation of the c5b-9 complex which damages tumor cells, killing them.
• For example, while C1q is necessary for proper apoptotic cell clearance in the peritoneal cavity, it is not important in the lungs where SP-D plays an important role.