carboxylesterases การใช้

• Carboxylesterases are widely distributed in nature, and are common in mammalian liver.
• The sequence of a number of type-B carboxylesterases indicates that the majority are evolutionarily related.
• Soman can also bind to other esterases, e . g ., AChE, cholinesterase ( ChE ) and carboxylesterases ( CarbE ).
• In rat plasma, cisatracurium is also metabolized by non-specific carboxylesterases ( a rate-limiting step ) to the monoquaternary alcohol and the monoquaternary acid.
• Its genome is deficient in the number of genes encoding detoxification enzymes, including cytochrome P450 monooxygenases ( P450s ), glutathione-S-transferases, and carboxylesterases.
• The specific function of this enzyme has not yet been determined; however, it is speculated that carboxylesterases may play a role in lipid metabolism and / or the blood brain barrier system.