carpaine การใช้

• The effects of carpaine may be related to its chelating structure.
• It is concluded from these results that carpaine affects the myocardium directly.
• "' Carpaine "'is one of the major alkaloid components of papaya leaves which has been studied for its cardiovascular effects.
• Circulatory effects of carpaine were studied in Wistar male rats weighing 314 + /-13 g, under pentobarbital ( 30 mg / kg ) anesthesia.
• Carpaine, 2 mg / kg, reduced cardiac output, stroke volume, stroke work, and cardiac power, but the calculated total peripheral resistance remained unchanged.
• Selective autonomic nervous blockade with atropine sulfate ( 1 mg / kg ) or propranolol hydrochloride ( 8 mg / kg ) did not alter the circulatory response to carpaine.
• Increasing dosages of carpaine from 0.5 mg / kg to 2.0 mg / kg resulted in progressive decrease in systolic, diastolic, and mean arterial blood pressure.