caspase การใช้

• ROS also causes a caspase independent pathway that results in apoptosis.
• DFF becomes activated when DFFA is cleaved by caspase-3.
• Caspase inhibitors are proposed drugs that would block the action of caspases.
• A caspase 9 knock-out leads to a severe brain malformation.
• Researchers decided upon the nomenclature of the caspase in 1996.
• This could activate caspase-2 and induce cell apoptosis.
• Podoptosis is caspase-independent and, therefore, different from apoptosis.
• Active Caspase 1 contains two heterodimers of p20 and p10.
• Active caspase-3 and-7 coimmunoprecipitated with survivin.
• Survivin also does not bind to active caspase-8.
• Pro-caspase-2 contains two subunits, p19 and p12.
• NOD1 protein contains a caspase recruitment domain ( CARD ).
• ICAD has two caspase recognition sites at Asp117 and Asp224.
• Unlike in apoptosis, necrosis and necroptosis do not involve caspase activation.
• The mechanism linking caspase-11 to NLRP3 is not currently known.
• Caspase inhibition may turn out to be the magic bullet against neurodegenerative diseases,
• ICE was, therefore, renamed as caspase 1.
• The cowpox L-18 processing by the cysteine protease caspase-1.
• The enzyme responsible for apoptotic DNA fragmentation is the Caspase-activated DNase.
• Another targeted molecule for cancer therapy involves the caspase family and their regulators.