ccoi การใช้

• CCOI is coded for by the mitochondrial chromosome.
• This can give rise to a mitochondrion with primarily or solely CCOI-mutated chromosomes.
• It is not clear why a deficiency of CCOI should have a positive selective bias.
• In colonic cancers, up to 80 % of tumor cells can be deficient in CCOI.
• Greaves et al . showed that deficiencies of CCOI in colonic crypts are due to mutations in the CCOI gene.
• Greaves et al . showed that deficiencies of CCOI in colonic crypts are due to mutations in the CCOI gene.
• CCOI protein is usually expressed at a high level in the cytoplasm of colonic crypts of the human large intestine ( colon ).
• Overall, the percent of crypts deficient for CCOI is less than 1 % before age 40, but then increases linearly with age.
• Overall, the percentage of crypts deficient for CCOI is less than 1 % before age 40, but then increases linearly with age.
• Colonic tumors often arise in a field of crypts containing a large cluster ( as many as 410 ) of CCOI-de
  鹀ient crypts.
• Nevertheless, the frequent occurrence of CCOI deficiency in many crypts within a colon epithelium indicates that absence of CCOI likely provides a selective advantage.
• Nevertheless, the frequent occurrence of CCOI deficiency in many crypts within a colon epithelium indicates that absence of CCOI likely provides a selective advantage.
• In humans, the percent of colonic crypts deficient for CCOI is less than 1 % before age 40, but then increases linearly with age.
• One suggestion These two factors may contribute to the frequent occurrence of CCOI-deficient colonic crypts with age or during carcinogenesis in the human colon.
• Colonic crypts deficient for CCOI in women reaches, on average, 18 % in women and 23 % in men by 80 84 years of age.
• On average, the percent of colonic crypts deficient for CCOI reaches 18 % in women and 23 % in men by 80 84 years of age.
• If a mutation occurs in CCOI in one chromosome of a mitochondrion, there may be random segregation of the chromosomes during mitochondrial fission to generate new mitochondria.
• Most crypts deficient in CCOI are in clusters of crypts ( clones of crypts ) with two or more CCOI-deficient crypts adjacent to each other ( see panel D ).
• Most crypts deficient in CCOI are in clusters of crypts ( clones of crypts ) with two or more CCOI-deficient crypts adjacent to each other ( see panel D ).