charybdotoxin การใช้

• In this state BK channels can still be inhibited by one of their inhibitors, like charybdotoxin ( CTX ).
• The amino terminal region of Pi3 lacks three residues when compared to other toxins of the same family e . g . charybdotoxin.
• K v 1.3 is blocked margatoxin, kaliotoxin, charybdotoxin, noxiustoxin, anuroctoxin ) and sea anemone ( anti-mycobacterial activity, but could well have been an immunomodulatory effect by clofazimine.
• These interactions are relatively weak at the physiological ionic strength ( 0.14M NaCl ) : ~ 3 to 4 kcal / mol for small cationic proteins, such as cytochrome c, charybdotoxin or hisactophilin.
• The three-dimensional structure of Pi3 is similar to other potassium channel blocking toxins like Charybdotoxin, because it has three disulphide bridges that stabilize two strands of beta sheet structures and a short alpha helix.
• "' Charybdotoxin "'( CTX ) is a 37 amino acid neurotoxin from the venom of the scorpion " Leiurus quinquestriatus hebraeus " ( Deathstalker ) that blocks calcium-activated potassium channels.