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chronaxie การใช้

ประโยคมือถือ
  • Lapicque used constant-current, capacitor-discharge pulses to obtain chronaxie for a wide variety of excitable tissues.
  • As mentioned, the two important points on the curve are rheobase ( b ) and chronaxie ( c ), which correlates to twice the rheobase ( 2b ).
  • Measurement of chronaxie and rheobase in sural sensory fibers has revealed mild reductions in excitability in diabetics, as evidenced by significant reductions in conduction velocity and chronaxie of sensory fibers with corresponding increases in rheobase.
  • Measurement of chronaxie and rheobase in sural sensory fibers has revealed mild reductions in excitability in diabetics, as evidenced by significant reductions in conduction velocity and chronaxie of sensory fibers with corresponding increases in rheobase.
  • Another factor is that cardiac tissue has a chronaxie ( response time ) of about 3 milliseconds, so electricity at frequencies of higher than about 333 Hz requires more current to cause fibrillation than is required at lower frequencies.
  • Despite this limitation, Weiss s equation provides the best fit for strength-duration data and indicates that rheobase and time constant ( chronaxie ) can be measured from the charge duration curve with a very small margin of error.
  • Mathematically, rheobase is equivalent to half the current that needs to be applied for the duration of chronaxie, which is a strength-duration time constant that corresponds to the duration of time that elicits a response when the nerve is stimulated at twice rheobasic strength.
  • Additionally, multiple measures of excitability in the TROND protocol permit assessment of ion channels ( transient and persistent Na + channels, slow K + channels ) at nodes of Ranvier by computing stimulus response curves, strength duration time constant ( chronaxie ), rheobase, and the recovery cycle after passage of an action potential.